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KMID : 1130620150110020164
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Journal of Clinical Neurology
2015 Volume.11 No. 2 p.164 ~ p.171
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Granulocyte Colony-Stimulating Factor for Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study of Iranian Patients
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Amirzagr Nasibeh
Nafissi Shahriar
Tafakhori Abbas
Modabbernia Amirhossein
Amirzargar Aliakbar
Ghaffarpour Majid
Siroos Bahaddin
Harirchian Mohammad Hossein
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Abstract
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Background and Purpose: The aim of this study was to determine the efficacy and tolerability of granulocyte colony-stimulating factor (G-CSF) in subjects with amyotrophic lateral sclerosis (ALS).
Methods: Forty subjects with ALS were randomly assigned to two groups, which received either subcutaneous G-CSF (5 μg/kg/q12h) or placebo for 5 days. The subjects were then followed up for 3 months using the ALS Functional Rating Scale-Revised (ALSFRS-R), manual muscle testing, ALS Assessment Questionnaire-40, and nerve conduction studies. CD34+/CD133+ cell count and monocyte chemoattractant protein-1 (MCP-1) levels were evaluated at baseline.
Results: The rate of disease progression did not differ significantly between the two groups. The reduction in ALSFRS-R scores was greater in female subjects in the G-CSF group than in their counterparts in the placebo group. There was a trend toward a positive correlation between baseline CSF MCP-1 levels and the change in ALSFRS-R scores in both groups (Spearman's ρ=0.370, p=0.070).
Conclusions: With the protocol implemented in this study, G-CSF is not a promising option for the treatment of ALS. Furthermore, it may accelerate disease progression in females.
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KEYWORD
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amyotrophic lateral sclerosis, ALS Functional Rating Scale, granulocyte colony-stimulating factor, CD34+/CD133+ cells, monocyte chemoattractant protein-1, compound motor action potential
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